Live Attenuated Cold-Adapted Influenza Vaccines
نویسندگان
چکیده
منابع مشابه
Development of Cold-adapted Recombinant Live, Attenuated Influenza a Vaccines in the U.s.a. and U.s.s.r
Influenza remains a major public health problem in many countries. Periodic epidemics disrupt economic and social activities within entire communities, impose sudden large demands on available medical facilities, and can cause excess mortality, particularly in the elderly or those with certain chronic illnesses [5,7,21]. Vaccination can provide significant protection against infection and illne...
متن کاملInfluenza Vaccination Strategies: Comparing Inactivated and Live Attenuated Influenza Vaccines
Influenza is a major respiratory pathogen causing annual outbreaks and occasional pandemics. Influenza vaccination is the major method of prophylaxis. Currently annual influenza vaccination is recommended for groups at high risk of complications from influenza infection such as pregnant women, young children, people with underlying disease and the elderly, along with occupational groups such a ...
متن کاملUse of live cold-adapted influenza A H1N1 and H3N2 virus vaccines in seropositive adults.
To investigate the immunogenicity and protective efficacy of cold-adapted influenza vaccine in individuals with underlying immunity to influenza A virus, we administered cold-adapted H1N1 and H3N2 vaccines to adults with prevaccination serum hemagglutination inhibition antibody titers of 1:16 or more and challenged them 1 month afterwards with homologous wild-type influenza A virus. Both cold-a...
متن کاملInfluenza viruses with rearranged genomes as live-attenuated vaccines.
H5N1 and H9N2 avian influenza virus subtypes top the World Health Organization's list for the greatest pandemic potential. Inactivated H5N1 vaccines induce limited immune responses and, in the case of live-attenuated influenza virus vaccines (LAIV), there are safety concerns regarding the possibility of reassortment between the H5 gene segment and circulating influenza viruses. In order to over...
متن کاملLive attenuated and inactivated influenza vaccines in children.
BACKGROUND Live attenuated influenza vaccine (LAIV) and inactivated influenza vaccine (IIV) are available for children. Local and systemic immunity induced by LAIV followed a month later by LAIV and IIV followed by LAIV were investigated with virus recovery after LAIV doses as surrogates for protection against influenza on natural exposure. METHODS Fifteen children received IIV followed by LA...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Perspectives in Medicine
سال: 2020
ISSN: 2157-1422
DOI: 10.1101/cshperspect.a038653